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Journal: Frontiers in Pharmacology
Article Title: γ-Mangostin attenuates osteoclastogenesis and bone resorption by suppressing the PI3K/AKT/NF-κB pathway
doi: 10.3389/fphar.2025.1742401
Figure Lengend Snippet: Cytotoxicity of γ-Mangostin (γ-Mag) in BMMs (A) Chemical structure of γ-Mag. (B) Viability of BMMs treated with increasing concentrations of γ-Mag for 48 h, assessed by MTS assay. (C) Viability of BMMs treated with 4 μM γ-Mag over time, measured by MTS assay. Data are presented as mean ± S.E.M. from three independent experiments, each performed with six replicates per group (n = 6). * P < 0.05, ** P < 0.01 compared to the 0 μM group. One-way ANOVA followed by Tukey’s post hoc test was used for statistical analysis. OD, optical density; M-CSF, macrophage colony-stimulating factor; γ-Mag, γ-Mangostin; BMMs, bone marrow-derived macrophages; MTS, multiple tumor suppressor.
Article Snippet:
Techniques: MTS Assay, Derivative Assay